Therapeutic Potentials of an Artificial Oxygen-Carrier, Liposome-Encapsulated Hemoglobin, for Ischemia/Reperfusion-Induced Cerebral Dysfunction in Rats

• Principais autores: Jin Kakehata (Autor), Taku Yamaguchi (Autor), Hiroko Togashi (Autor), Ichiro Sakuma (Autor), Hiroshi Otani (Autor), Yuji Morimoto (Autor), Mitsuhiro Yoshioka (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2010-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

We performed this study to elucidate whether a newly developed liposome-encapsulated hemoglobin, TRM-645 (TRM), can prevent cerebral dysfunction resulting from acute ischemic stroke when used as an oxygen carrier. Hippocampal long-term potentiation (LTP) in the perforant path-dentate gyrus synapses...