Artesunate Therapy Alleviates Fracture-Associated Chronic Pain After Orthopedic Surgery by Suppressing CCL21-Dependent TREM2/DAP12 Inflammatory Signaling in Mice

• Главные авторы: Linlin Zhang (Автор), Nan Li (Автор), Haoyue Zhang (Автор), Yigang Wang (Автор), Tianyu Gao (Автор), Yuying Zhao (Автор), Guolin Wang (Автор), Yonghao Yu (Автор), Chunyan Wang (Автор), Yize Li (Автор)
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• Опубликовано: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Предметы: article
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Chronic pain after bone fracture and orthopedic surgery is often refractory to most analgesics currently in use, thus emphasizing the urgent need for improved therapeutic medications. Chemokine-dependent neuroinflammation is critical for excitatory synaptic plasticity and central nociception sensiti...