Artesunate Therapy Alleviates Fracture-Associated Chronic Pain After Orthopedic Surgery by Suppressing CCL21-Dependent TREM2/DAP12 Inflammatory Signaling in Mice

• Main Authors: Linlin Zhang (Author), Nan Li (Author), Haoyue Zhang (Author), Yigang Wang (Author), Tianyu Gao (Author), Yuying Zhao (Author), Guolin Wang (Author), Yonghao Yu (Author), Chunyan Wang (Author), Yize Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic pain after bone fracture and orthopedic surgery is often refractory to most analgesics currently in use, thus emphasizing the urgent need for improved therapeutic medications. Chemokine-dependent neuroinflammation is critical for excitatory synaptic plasticity and central nociception sensiti...