Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms

• Главные авторы: Vinita A. Hajeri (Автор), James F. Amatruda (Автор)
• Формат: ‌
• Опубликовано: The Company of Biologists, 2012-01-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

The post-genomic era is marked by a pressing need to functionally characterize genes through understanding gene-gene interactions, as well as interactions between biological pathways. Exploiting a phenomenon known as synthetic lethality, in which simultaneous loss of two interacting genes leads to l...