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Enhancing Dissolution and Oral Bioavailability of Ursodeoxycholic Acid with a Spray-Dried pH-Modified Extended Release Formulation

Ursodeoxycholate (UDCA) has low oral bioavailability and pH-dependent solubility and permeability. Thus, we developed a pH-modified extended-release formulation of UDCA using Na<sub>2</sub>CO<sub>3</sub> as the alkalizing agent and hydroxypropyl methylcellulose (HPMC) as the...

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Bibliographic Details
Main Authors:	Jaehyeok Lee (Author), Chul Haeng Lee (Author), Jong-Geon Lee (Author), So Yeon Jeon (Author), Min-Koo Choi (Author), Im-Sook Song (Author)
Format:	Book
Published:	MDPI AG, 2022-05-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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