Sunitinib induced hepatotoxicity in L02 cells via ROS-MAPKs signaling pathway

• Main Authors: Ting-Li Tang (Author), Yan Yang (Author), Lin Guo (Author), Shuang Xia (Author), Bikui Zhang (Author), Miao Yan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sunitinib is a multi-targeted tyrosine kinase inhibitor with remarkable anticancer activity, while hepatotoxicity is a potentially fatal adverse effect of its administration. The aim of this study was to elucidate the mechanism of hepatotoxicity induced by Sunitinib and the protective effect of glyc...