Sunitinib induced hepatotoxicity in L02 cells via ROS-MAPKs signaling pathway

• Главные авторы: Ting-Li Tang (Автор), Yan Yang (Автор), Lin Guo (Автор), Shuang Xia (Автор), Bikui Zhang (Автор), Miao Yan (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Sunitinib is a multi-targeted tyrosine kinase inhibitor with remarkable anticancer activity, while hepatotoxicity is a potentially fatal adverse effect of its administration. The aim of this study was to elucidate the mechanism of hepatotoxicity induced by Sunitinib and the protective effect of glyc...