Montelukast Disposition: No Indication of Transporter-Mediated Uptake in OATP2B1 and OATP1B1 Expressing HEK293 Cells

• Main Authors: Marie Brännström (Author), Pär Nordell (Author), Britta Bonn (Author), Andrew M. Davis (Author), Anna-Pia Palmgren (Author), Constanze Hilgendorf (Author), Katarina Rubin (Author), Ken Grime (Author)
• Format: Book
• Published: MDPI AG, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clinical studies with montelukast show variability in effect and polymorphic OATP2B1-dependent absorption has previously been implicated as a possible cause. This claim has been challenged with conflicting data and here we used OATP2B1-transfected HEK293 cells to clarify the mechanisms involved. For...