Montelukast Disposition: No Indication of Transporter-Mediated Uptake in OATP2B1 and OATP1B1 Expressing HEK293 Cells

• প্রধান লেখক: Marie Brännström (লেখক), Pär Nordell (লেখক), Britta Bonn (লেখক), Andrew M. Davis (লেখক), Anna-Pia Palmgren (লেখক), Constanze Hilgendorf (লেখক), Katarina Rubin (লেখক), Ken Grime (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2015-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Clinical studies with montelukast show variability in effect and polymorphic OATP2B1-dependent absorption has previously been implicated as a possible cause. This claim has been challenged with conflicting data and here we used OATP2B1-transfected HEK293 cells to clarify the mechanisms involved. For...