Montelukast Disposition: No Indication of Transporter-Mediated Uptake in OATP2B1 and OATP1B1 Expressing HEK293 Cells

• Egile Nagusiak: Marie Brännström (Egilea), Pär Nordell (Egilea), Britta Bonn (Egilea), Andrew M. Davis (Egilea), Anna-Pia Palmgren (Egilea), Constanze Hilgendorf (Egilea), Katarina Rubin (Egilea), Ken Grime (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2015-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Clinical studies with montelukast show variability in effect and polymorphic OATP2B1-dependent absorption has previously been implicated as a possible cause. This claim has been challenged with conflicting data and here we used OATP2B1-transfected HEK293 cells to clarify the mechanisms involved. For...