Simultaneous Imaging and Therapy Using Epitope-Specific Anti-Epidermal Growth Factor Receptor (EGFR) Antibody Conjugates

• Egile Nagusiak: Anjong Florence Tikum (Egilea), Anand Krishnan Nambisan (Egilea), Jessica Pougoue Ketchemen (Egilea), Hanan Babeker (Egilea), Musharraf N. Khan (Egilea), Emina E. Torlakovic (Egilea), Humphrey Fonge (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-09-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Matuzumab and nimotuzumab are anti-EGFR monoclonal antibodies that bind to different epitopes of domain III of EGFR. We developed ⁸⁹Zr-matuzumab as a PET probe for diagnosis/monitoring of response to treatment of a noncompeting anti-EGFR nimotuzumab antibody drug conjugate (AD...