Simultaneous Imaging and Therapy Using Epitope-Specific Anti-Epidermal Growth Factor Receptor (EGFR) Antibody Conjugates

• Главные авторы: Anjong Florence Tikum (Автор), Anand Krishnan Nambisan (Автор), Jessica Pougoue Ketchemen (Автор), Hanan Babeker (Автор), Musharraf N. Khan (Автор), Emina E. Torlakovic (Автор), Humphrey Fonge (Автор)
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• Опубликовано: MDPI AG, 2022-09-01T00:00:00Z.
• Предметы: article
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Matuzumab and nimotuzumab are anti-EGFR monoclonal antibodies that bind to different epitopes of domain III of EGFR. We developed ⁸⁹Zr-matuzumab as a PET probe for diagnosis/monitoring of response to treatment of a noncompeting anti-EGFR nimotuzumab antibody drug conjugate (AD...