Inhibition of Indigoidine Synthesis as a High-Throughput Colourimetric Screen for Antibiotics Targeting the Essential <i>Mycobacterium tuberculosis</i> Phosphopantetheinyl Transferase PptT

A recently-validated and underexplored drug target in <i>Mycobacterium tuberculosis</i> is PptT, an essential phosphopantetheinyl transferase (PPTase) that plays a critical role in activating enzymes for both primary and secondary metabolism. PptT possesses a deep binding pocket that doe...

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Bibliographic Details
Main Authors: Alistair S. Brown (Author), Jeremy G. Owen (Author), James Jung (Author), Edward N. Baker (Author), David F. Ackerley (Author)
Format: Book
Published: MDPI AG, 2021-07-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
Copy 1 Available