Functionalized Caprolactone-Polyethylene Glycol Based Thermo-Responsive Hydrogels of Silibinin for the Treatment of Malignant Melanoma

• Main Authors: Behzad Sharif Makhmalzadeh (Author), Ommoleila Molavi (Author), Mohammad Reza Vakili (Author), Hai-Feng Zhang (Author), Amir Solimani (Author), Hoda Soleymani Abyaneh (Author), Raimar Loebenberg (Author), Raymond Lai (Author), Afsaneh Lavasanifar (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Silibinin, is a natural compound, which has shown anticancer activity in various malignancies. In this study, we evaluated the anticancer effects of silibinin in B16-F10 melanoma cells and developed a novel thermoresponsive hydrogel for local delivery of this compound. Method: A thermorespo...