Angiotensin II mediates hypertensive cardiac fibrosis via an Erbb4-IR-dependent mechanism

• Main Authors: Jian-Chun Li (Author), Jian Jia (Author), Li Dong (Author), Zhong-Jing Hu (Author), Xiao-Ru Huang (Author), Hong-Lian Wang (Author), Li Wang (Author), Si-Jin Yang (Author), Hui-Yao Lan (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transforming growth factor β (TGF-β)/Smad3 plays a vital role in hypertensive cardiac fibrosis. The long non-coding RNA (lncRNA) Erbb4-IR is a novel Smad3-dependent lncRNA that mediates kidney fibrosis. However, the role of Erbb4-IR in hypertensive heart disease remains unexplored and was investigat...