CCR5 Disruption in Induced Pluripotent Stem Cells Using CRISPR/Cas9 Provides Selective Resistance of Immune Cells to CCR5-tropic HIV-1 Virus

• Auteurs principaux: HyunJun Kang (Auteur), Petra Minder (Auteur), Mi Ae Park (Auteur), Walatta-Tseyon Mesquitta (Auteur), Bruce E Torbett (Auteur), Igor I Slukvin (Auteur)
• Format: Livre
• Publié: Elsevier, 2015-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The chemokine (C-C motif) receptor 5 (CCR5) serves as an HIV-1 co-receptor and is essential for cell infection with CCR5-tropic viruses. Loss of functional receptor protects against HIV infection. Here, we report the successful targeting of CCR5 in GFP-marked human induced pluripotent stem cells (iP...