Olfactomedin-1 activity identifies a cell invasion checkpoint during epithelial-mesenchymal transition in the chick embryonic heart

• Principais autores: Alejandro Lencinas (Autor), Danny C. Chhun (Autor), Kelvin P. Dan (Autor), Kristen D. Ross (Autor), Elizabeth A. Hoover (Autor), Parker B. Antin (Autor), Raymond B. Runyan (Autor)
• Formato: Livro
• Publicado em: The Company of Biologists, 2013-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

SUMMARY Endothelia in the atrioventricular (AV) canal of the developing heart undergo a prototypical epithelial mesenchymal transition (EMT) to begin heart valve formation. Using an in vitro invasion assay, an extracellular matrix protein, Olfactomedin-1 (OLFM1), was found to increase mesenchymal ce...