Olfactomedin-1 activity identifies a cell invasion checkpoint during epithelial-mesenchymal transition in the chick embryonic heart

• Main Authors: Alejandro Lencinas (Author), Danny C. Chhun (Author), Kelvin P. Dan (Author), Kristen D. Ross (Author), Elizabeth A. Hoover (Author), Parker B. Antin (Author), Raymond B. Runyan (Author)
• Format: Book
• Published: The Company of Biologists, 2013-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Endothelia in the atrioventricular (AV) canal of the developing heart undergo a prototypical epithelial mesenchymal transition (EMT) to begin heart valve formation. Using an in vitro invasion assay, an extracellular matrix protein, Olfactomedin-1 (OLFM1), was found to increase mesenchymal ce...