Nonhuman Primates and Humanized Mice for Studies of HIV-1 Integrase Inhibitors: A Review

• 主要な著者: Said A. Hassounah (著者), Thibault Mesplède (著者), Mark A. Wainberg (著者)
• フォーマット: 図書
• 出版事項: Case Western Reserve University, 2016-05-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Since the discovery of the first inhibitors of HIV replication, drug resistance has been a major problem in HIV therapy, due, in part, to the high mutation rate of HIV. Therefore, the development of a predictive animal model is important to identify impending resistance mutations and to possibly inf...