Transcriptotype-Driven Discovery of Apigenin as a Therapy against Cholestatic Liver Fibrosis: Through Inhibition of PANoptosis and Following Type-I Interferon Responses

• Main Authors: Shuni Duan (Author), Xin Li (Author), Junsong Han (Author), Yang Yang (Author), Ranyi Luo (Author), Yajie Cai (Author), Xiaojiaoyang Li (Author), Qi Zheng (Author), Jincheng Guo (Author), Runping Liu (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cholangiopathies lack effective medicines and can progress into end-stage liver diseases. Mining natural product transcriptome databases for bioactive ingredients, which can reverse disease-associated transcriptomic phenotypes, holds promise as an effective approach for drug discovery. To identify d...