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Metformin enhances anti-tumor effect of L-type amino acid transporter 1 (LAT1) inhibitor

Background: In many cancer cells, L-type amino acid transporter 1 (LAT1) transports neutral amino acids with bulky side chain, which activate mammalian target of rapamycin (mTOR) to cause cell proliferation. An anti-diabetic drug, metformin, has been shown to activate AMP-activated protein kinase (A...

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Main Authors: Seiji Ueno (Author), Toru Kimura (Author), Takashi Yamaga (Author), Akihiko Kawada (Author), Toshiaki Ochiai (Author), Hitoshi Endou (Author), Hiroyuki Sakurai (Author)
Format: Book
Published: Elsevier, 2016-06-01T00:00:00Z.
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