Selective inhibition of CDK4/6: A safe and effective strategy for developing anticancer drugs

• Ngā kaituhi matua: Kai Yuan (Author), Xiao Wang (Author), Haojie Dong (Author), Wenjian Min (Author), Haiping Hao (Author), Peng Yang (Author)
• Hōputu: Pukapuka
• I whakaputaina: Elsevier, 2021-01-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

The sustained cell proliferation resulting from dysregulation of the cell cycle and activation of cyclin-dependent kinases (CDKs) is a hallmark of cancer. The inhibition of CDKs is a highly promising and attractive strategy for the development of anticancer drugs. In particular, third-generation CDK...