Synthesis of Celecoxib-Eutectic Mixture Particles via Supercritical CO₂ Process and Celecoxib Immediate Release Tablet Formulation by Quality by Design Approach

• Main Authors: Seung-Hyeon Hong (Author), Linh Dinh (Author), Sharif Md Abuzar (Author), Eun Seok Lee (Author), Sung-Joo Hwang (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Significant improvements in the wettability and dissolution rate of celecoxib (CEL), a poorly soluble selective cyclooxygenase-2 (COX-2) inhibitor, have been shown by Huyn et al., 2019 by combining the binary pharmaceutical compositions including CEL and one of the two co-formers, adipic acid (ADI)...