A novel cell-free method to culture Schistosoma mansoni from cercariae to juvenile worm stages for in vitro drug testing.

• Main Authors: Sören Frahm (Author), Anisuzzaman Anisuzzaman (Author), Ulrich Fabien Prodjinotho (Author), Nermina Vejzagić (Author), Admar Verschoor (Author), Clarissa Prazeres da Costa (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:The arsenal in anthelminthic treatment against schistosomiasis is limited and relies almost exclusively on a single drug, praziquantel (PZQ). Thus, resistance to PZQ could constitute a major threat. Even though PZQ is potent in killing adult worms, its activity against earlier stages is l...