A novel cell-free method to culture Schistosoma mansoni from cercariae to juvenile worm stages for in vitro drug testing.

• Prif Awduron: Sören Frahm (Awdur), Anisuzzaman Anisuzzaman (Awdur), Ulrich Fabien Prodjinotho (Awdur), Nermina Vejzagić (Awdur), Admar Verschoor (Awdur), Clarissa Prazeres da Costa (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Public Library of Science (PLoS), 2019-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

BACKGROUND:The arsenal in anthelminthic treatment against schistosomiasis is limited and relies almost exclusively on a single drug, praziquantel (PZQ). Thus, resistance to PZQ could constitute a major threat. Even though PZQ is potent in killing adult worms, its activity against earlier stages is l...