5-HT1F Receptor Agonist Ameliorates Mechanical Allodynia in Neuropathic Pain via Induction of Mitochondrial Biogenesis and Suppression of Neuroinflammation

• Main Authors: Long-Qing Zhang (Author), Ya-Qun Zhou (Author), Jia-Yan Li (Author), Jia Sun (Author), Shuang Zhang (Author), Jia-Yi Wu (Author), Shao-Jie Gao (Author), Xue-Bi Tian (Author), Wei Mei (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neuropathic pain is a devastating disease that affects millions of people worldwide. Serotonin (5-hydroxytryptamine, 5-HT) is involved in pain modulation. Several lines of evidence have indicated that 5-HT1F receptor agonists are potent inducers of mitochondrial biogenesis. In this study, we tested...