Reversing the PAI-1-induced fibrotic immune exclusion of solid tumor by multivalent CXCR4 antagonistic nano-permeator

• Main Authors: Jingwen Dong (Author), Chenfei Zhu (Author), Ying Huang (Author), Quanhao Li (Author), Jing Li (Author), Zheng Wang (Author), Yixin Wang (Author), Zhanwei Zhou (Author), Minjie Sun (Author)
• Format: Book
• Published: Elsevier, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fibrosis is one of the key factors that lead to the immune exclusion of solid tumors. Although degradation of fiber is a promising strategy, its application was still bottlenecked by the side effects of causing metastasis, resulting in the failure of immunotherapy. Here, we developed an antimetastat...