Reversing the PAI-1-induced fibrotic immune exclusion of solid tumor by multivalent CXCR4 antagonistic nano-permeator

• Glavni autori: Jingwen Dong (Autor), Chenfei Zhu (Autor), Ying Huang (Autor), Quanhao Li (Autor), Jing Li (Autor), Zheng Wang (Autor), Yixin Wang (Autor), Zhanwei Zhou (Autor), Minjie Sun (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2023-07-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Fibrosis is one of the key factors that lead to the immune exclusion of solid tumors. Although degradation of fiber is a promising strategy, its application was still bottlenecked by the side effects of causing metastasis, resulting in the failure of immunotherapy. Here, we developed an antimetastat...