A Spontaneous Mutation in Taar1 Impacts Methamphetamine-Related Traits Exclusively in DBA/2 Mice from a Single Vendor

• Main Authors: Cheryl Reed (Author), Harue Baba (Author), Zhen Zhu (Author), Jason Erk (Author), John R. Mootz (Author), Nicholas M. Varra (Author), Robert W. Williams (Author), Tamara J. Phillips (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Major gene effects on traits associated with substance use disorders are rare. Previous findings in methamphetamine drinking (MADR) lines of mice, bred for high or low voluntary MA intake, and in null mutants demonstrate a major impact of the trace amine-associated receptor 1 (Taar1) gene on a triad...