A Spontaneous Mutation in Taar1 Impacts Methamphetamine-Related Traits Exclusively in DBA/2 Mice from a Single Vendor

• Главные авторы: Cheryl Reed (Автор), Harue Baba (Автор), Zhen Zhu (Автор), Jason Erk (Автор), John R. Mootz (Автор), Nicholas M. Varra (Автор), Robert W. Williams (Автор), Tamara J. Phillips (Автор)
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• Опубликовано: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Предметы: article
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Major gene effects on traits associated with substance use disorders are rare. Previous findings in methamphetamine drinking (MADR) lines of mice, bred for high or low voluntary MA intake, and in null mutants demonstrate a major impact of the trace amine-associated receptor 1 (Taar1) gene on a triad...