Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5×FAD mice

Clinical studies have shown that epileptic seizures worsen Alzheimer's disease (AD) pathology and related cognitive deficits; however, the underlying mechanism is unclear. To assess the effects of seizures on the progression of AD, chronic temporal lobe epilepsy was induced in five familial AD...

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Main Authors: Yulian Zou (Author), Chengyan Wang (Author), Huang Li (Author), Meihua Zhong (Author), Jin Lin (Author), Yan Hu (Author), Zhou Chen (Author), Chen-Ling Gan (Author)
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Publicado em: Frontiers Media S.A., 2024-10-01T00:00:00Z.
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