Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5×FAD mice

• Main Authors: Yulian Zou (Author), Chengyan Wang (Author), Huang Li (Author), Meihua Zhong (Author), Jin Lin (Author), Yan Hu (Author), Zhou Chen (Author), Chen-Ling Gan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clinical studies have shown that epileptic seizures worsen Alzheimer's disease (AD) pathology and related cognitive deficits; however, the underlying mechanism is unclear. To assess the effects of seizures on the progression of AD, chronic temporal lobe epilepsy was induced in five familial AD...