Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties
The DNA methyltransferases (DNMTs) were found in mammals to maintain DNA methylation. Among them, DNMT1 was the first identified, and it is an attractive target for tumour chemotherapy. DC_05 and DC_517 have been reported in our previous work, which is non-nucleoside DNMT1 inhibitor with low micromo...
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Main Authors: | , , , , , , , , , , , , , |
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Format: | Book |
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Taylor & Francis Group,
2022-12-01T00:00:00Z.
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A1234.567 |
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