Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties

• Główni autorzy: Ennian Li (Autor), Kai Wang (Autor), Bei Zhang (Autor), Siqi Guo (Autor), Senhao Xiao (Autor), Qi Pan (Autor), Xiaowan Wang (Autor), Weiying Chen (Autor), Yunshan Wu (Autor), Hesong Xu (Autor), Xiangqian Kong (Autor), Cheng Luo (Autor), Shijie Chen (Autor), Bo Liu (Autor)
• Format: Książka
• Wydane: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The DNA methyltransferases (DNMTs) were found in mammals to maintain DNA methylation. Among them, DNMT1 was the first identified, and it is an attractive target for tumour chemotherapy. DC_05 and DC_517 have been reported in our previous work, which is non-nucleoside DNMT1 inhibitor with low micromo...