Limited Associations Between 5-HT Receptor Gene Polymorphisms and Treatment Response in Antidepressant Treatment-Free Patients With Depression

• Main Authors: Taichi Ochi (Author), Natalya M. Vyalova (Author), Innokentiy S. Losenkov (Author), Diana Z. Paderina (Author), Ivan V. Pozhidaev (Author), Anton J. M. Loonen (Author), German G. Simutkin (Author), Nikolay A. Bokhan (Author), Svetlana A. Ivanova (Author), Bob Wilffert (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Major depressive disorder has become a prominent cause of disability, as lifetime prevalence has increased to ~15% in the Western world. Pharmacological effects of serotonin (5-hydroxytryptamine, 5-HT) are mediated through 5-hydroxytryptamine receptor (5-HTR) binding. Serotonin regulation of amygdal...