Onchocerciasis Drug Discovery: In Vitro Evaluation of FDA-Approved Drugs against <i>Onchocerca gutturosa</i> in Gambia

• Main Authors: Suzanne Gokool (Author), Simon Townson (Author), Andrew Freeman (Author), Jadzia Siemienski-Kleyn (Author), Jakub Zubrzycki (Author), Senyo Tagboto (Author), Marc P. Hübner (Author), Ivan Scandale (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Onchocerciasis treatment and control relies mainly on the use of ivermectin which has high activity against the microfilarial stage of <i>Onchocerca volvulus</i> but limited activity against the long-lived, tissue dwelling adult nematodes. As this neglected tropical disease has now been...