Comparison of an Addictive Potential of μ-Opioid Receptor Agonists with G Protein Bias: Behavioral and Molecular Modeling Studies

• Päätekijät: Lucja Kudla (Tekijä), Ryszard Bugno (Tekijä), Sabina Podlewska (Tekijä), Lukasz Szumiec (Tekijä), Lucja Wiktorowska (Tekijä), Andrzej J. Bojarski (Tekijä), Ryszard Przewlocki (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2021-12-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Among different approaches to the search for novel-safer and less addictive-opioid analgesics, biased agonism has received the most attention in recent years. Some μ-opioid receptor agonists with G protein bias, including SR compounds, were proposed to induce diminished side effects. However, in man...