Early-Life Stress Induces Depression-Like Behavior and Synaptic-Plasticity Changes in a Maternal Separation Rat Model: Gender Difference and Metabolomics Study

• Main Authors: Yongfei Cui (Author), Kerun Cao (Author), Huiyuan Lin (Author), Sainan Cui (Author), Chongkun Shen (Author), Wenhao Wen (Author), Haixin Mo (Author), Zhaoyang Dong (Author), Shasha Bai (Author), Lei Yang (Author), Yafei Shi (Author), Rong Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

More than 300 million people suffer from depressive disorders globally. People under early-life stress (ELS) are reportedly vulnerable to depression in their adulthood, and synaptic plasticity can be the molecular mechanism underlying such depression. Herein, we simulated ELS by using a maternal sep...