Angiotensin Type-1 Receptor Inhibition Reduces NLRP3 Inflammasome Upregulation Induced by Aging and Neurodegeneration in the <i>Substantia Nigra</i> of Male Rodents and Primary Mesencephalic Cultures

• Hauptverfasser: Aloia Quijano (Verfasst von), Carmen Diaz-Ruiz (Verfasst von), Andrea Lopez-Lopez (Verfasst von), Begoña Villar-Cheda (Verfasst von), Ana Muñoz (Verfasst von), Ana I. Rodriguez-Perez (Verfasst von), Jose L. Labandeira-Garcia (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2022-02-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

The tissue renin-angiotensin system (RAS) has been shown to be involved in prooxidative and proinflammatory changes observed in aging and aging-related diseases such as dopaminergic degeneration in Parkinson's disease (PD). We studied the activation of the NLRP3 inflammasome in the <i>sub...