Design, synthesis and docking study of 3,4-dihydropyrimidine-2-one derivatives as inhibitors of the Mitotic Kinesin, Eg5

• Main Authors: Hossein Sadeghpour (Author), Ramin Miri (Author), Seyed Ahmad Ebadi (Author), Shima Mohammadebrahimi (Author), Elham Riazimontazer (Author)
• Format: Book
• Published: Shiraz University of Medical Sciences, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of 3,4-dihydropyrimidine-2-one derivatives were designed and synthesized as monastrol analogs by Biginelli cyclocondensation of a β-keto compounds and aromatic aldehyde with urea or thiourea. Biginelli cyclocondensation usually produces racemic mixtures of 3,4-dihydropyrimidine-2-ones. Enan...