Design, synthesis and docking study of 3,4-dihydropyrimidine-2-one derivatives as inhibitors of the Mitotic Kinesin, Eg5

• Auteurs principaux: Hossein Sadeghpour (Auteur), Ramin Miri (Auteur), Seyed Ahmad Ebadi (Auteur), Shima Mohammadebrahimi (Auteur), Elham Riazimontazer (Auteur)
• Format: Livre
• Publié: Shiraz University of Medical Sciences, 2023-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

A series of 3,4-dihydropyrimidine-2-one derivatives were designed and synthesized as monastrol analogs by Biginelli cyclocondensation of a β-keto compounds and aromatic aldehyde with urea or thiourea. Biginelli cyclocondensation usually produces racemic mixtures of 3,4-dihydropyrimidine-2-ones. Enan...