Design, synthesis and docking study of 3,4-dihydropyrimidine-2-one derivatives as inhibitors of the Mitotic Kinesin, Eg5

• Κύριοι συγγραφείς: Hossein Sadeghpour (Συγγραφέας), Ramin Miri (Συγγραφέας), Seyed Ahmad Ebadi (Συγγραφέας), Shima Mohammadebrahimi (Συγγραφέας), Elham Riazimontazer (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Shiraz University of Medical Sciences, 2023-09-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

A series of 3,4-dihydropyrimidine-2-one derivatives were designed and synthesized as monastrol analogs by Biginelli cyclocondensation of a β-keto compounds and aromatic aldehyde with urea or thiourea. Biginelli cyclocondensation usually produces racemic mixtures of 3,4-dihydropyrimidine-2-ones. Enan...