A Matrigel-based 3D construct of SH-SY5Y cells models the α-synuclein pathologies of Parkinson's disease

• Үндсэн зохиолчид: Zhao-Feng Li (Зохиогч), Lei Cui (Зохиогч), Mi-Mi Jin (Зохиогч), Dong-Yan Hu (Зохиогч), Xiao-Gang Hou (Зохиогч), Shu-Shu Liu (Зохиогч), Xiong Zhang (Зохиогч), Jian-Hong Zhu (Зохиогч)
• Формат: Ном
• Хэвлэсэн: The Company of Biologists, 2022-03-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Parkinson's disease (PD) is associated with α-synuclein-based Lewy body pathology, which has been difficult to observe in conventional two-dimensional (2D) cell culture and even in animal models. We herein aimed to develop a three-dimensional (3D) cellular model of PD to recapitulate the α-synu...