A Matrigel-based 3D construct of SH-SY5Y cells models the α-synuclein pathologies of Parkinson's disease

• Main Authors: Zhao-Feng Li (Author), Lei Cui (Author), Mi-Mi Jin (Author), Dong-Yan Hu (Author), Xiao-Gang Hou (Author), Shu-Shu Liu (Author), Xiong Zhang (Author), Jian-Hong Zhu (Author)
• Format: Book
• Published: The Company of Biologists, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) is associated with α-synuclein-based Lewy body pathology, which has been difficult to observe in conventional two-dimensional (2D) cell culture and even in animal models. We herein aimed to develop a three-dimensional (3D) cellular model of PD to recapitulate the α-synu...