Target-Mediated Brain Tissue Binding for Small Molecule Inhibitors of Heat Shock Protein 90

• Hoofdauteurs: Lassina Badolo (Auteur), Kenneth Thirstrup (Auteur), Søren Møller Nielsen (Auteur), Ask Püschl (Auteur), Thomas Jensen (Auteur), Steve Watson (Auteur), Christoffer Bundgaard (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2020-10-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Drug distribution in the brain is generally associated with an affinity for fatty brain tissues and therefore known to be species- and concentration-independent. We report here the effect of target affinity on brain tissue binding for 10 small molecules designed to inhibit brain heat shock protein 9...