Target-Mediated Brain Tissue Binding for Small Molecule Inhibitors of Heat Shock Protein 90

Target-Mediated Brain Tissue Binding for Small Molecule Inhibitors of Heat Shock Protein 90

Drug distribution in the brain is generally associated with an affinity for fatty brain tissues and therefore known to be species- and concentration-independent. We report here the effect of target affinity on brain tissue binding for 10 small molecules designed to inhibit brain heat shock protein 9...

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Main Authors: Lassina Badolo (Author), Kenneth Thirstrup (Author), Søren Møller Nielsen (Author), Ask Püschl (Author), Thomas Jensen (Author), Steve Watson (Author), Christoffer Bundgaard (Author)
Format: Book
Published: MDPI AG, 2020-10-01T00:00:00Z.
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