Target-Mediated Brain Tissue Binding for Small Molecule Inhibitors of Heat Shock Protein 90

• Main Authors: Lassina Badolo (Author), Kenneth Thirstrup (Author), Søren Møller Nielsen (Author), Ask Püschl (Author), Thomas Jensen (Author), Steve Watson (Author), Christoffer Bundgaard (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug distribution in the brain is generally associated with an affinity for fatty brain tissues and therefore known to be species- and concentration-independent. We report here the effect of target affinity on brain tissue binding for 10 small molecules designed to inhibit brain heat shock protein 9...