Target-Mediated Brain Tissue Binding for Small Molecule Inhibitors of Heat Shock Protein 90

• Váldodahkkit: Lassina Badolo (Dahkki), Kenneth Thirstrup (Dahkki), Søren Møller Nielsen (Dahkki), Ask Püschl (Dahkki), Thomas Jensen (Dahkki), Steve Watson (Dahkki), Christoffer Bundgaard (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2020-10-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Drug distribution in the brain is generally associated with an affinity for fatty brain tissues and therefore known to be species- and concentration-independent. We report here the effect of target affinity on brain tissue binding for 10 small molecules designed to inhibit brain heat shock protein 9...