EM-transcriptomic signature predicts drug response in advanced stages of high-grade serous ovarian carcinoma based on ascites-derived primary cultures

• Main Authors: Diana-Roxana Constantinescu (Author), Andrei Sorop (Author), Alina-Veronica Ghionescu (Author), Daniela Lixandru (Author), Vlad Herlea (Author), Nicolae Bacalbasa (Author), Simona Olimpia Dima (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: High-grade serous ovarian carcinoma (HGSOC) remains a medical challenge despite considerable improvements in the treatment. Unfortunately, over 75% of patients have already metastasized at the time of diagnosis. Advances in understanding the mechanisms underlying how ascites cause chem...