Icariin Ameliorates Diabetic Cardiomyopathy Through Apelin/Sirt3 Signalling to Improve Mitochondrial Dysfunction

• Main Authors: Tingjuan Ni (Author), Na Lin (Author), Xingxiao Huang (Author), Wenqiang Lu (Author), Zhenzhu Sun (Author), Jie Zhang (Author), Hui Lin (Author), Jufang Chi (Author), Hangyuan Guo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Myocardial contractile dysfunction in diabetic cardiomyocytes is a significant promoter of heart failure. Herein, we investigated the effect of icariin, a flavonoid monomer isolated from Epimedium, on diabetic cardiomyopathy (DCM) and explored the mechanisms underlying its unique pharmacological car...