Bleomycin administered by laser-assisted drug delivery or intradermal needle-injection results in distinct biodistribution patterns in skin: in vivo investigations with mass spectrometry imaging

• Main Authors: Kristoffer Hendel (Author), Anders C. N. Hansen (Author), Liora Bik (Author), Charlotte Bagger (Author), Martijn B. A. van Doorn (Author), Christian Janfelt (Author), Uffe H. Olesen (Author), Merete Haedersdal (Author), Catharina M. Lerche (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bleomycin (BLM) is being repositioned in dermato-oncology for intralesional and intra-tumoural use. Although conventionally administered by local needle injections (NIs), ablative fractional lasers (AFLs) can facilitate topical BLM delivery. Adding local electroporation (EP) can augment intracellula...