Bleomycin administered by laser-assisted drug delivery or intradermal needle-injection results in distinct biodistribution patterns in skin: in vivo investigations with mass spectrometry imaging

• Hauptverfasser: Kristoffer Hendel (Verfasst von), Anders C. N. Hansen (Verfasst von), Liora Bik (Verfasst von), Charlotte Bagger (Verfasst von), Martijn B. A. van Doorn (Verfasst von), Christian Janfelt (Verfasst von), Uffe H. Olesen (Verfasst von), Merete Haedersdal (Verfasst von), Catharina M. Lerche (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Bleomycin (BLM) is being repositioned in dermato-oncology for intralesional and intra-tumoural use. Although conventionally administered by local needle injections (NIs), ablative fractional lasers (AFLs) can facilitate topical BLM delivery. Adding local electroporation (EP) can augment intracellula...