The effects of the Histone Deacetylase (HDAC) Inhibitor 4-Phenylbutyrate on gap junction conductance and permeability

• Main Authors: Joshua eKaufman (Author), Chris eGordon (Author), Roberto eBergamaschi (Author), Hong Zhan Wang (Author), Ira S Cohen (Author), Virginijus eValiunas (Author), Peter eBrink (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Longitudinal resistance is a key factor in determining cardiac action potential propagation. Action potential conduction velocity has been shown to be proportional to the square root of longitudinal resistance. A major determinant of longitudinal resistance in myocardium is the gap junction channel,...