Control of HIV Infection In Vivo Using Gene Therapy with a Secreted Entry Inhibitor

• Auteurs principaux: Alexander Falkenhagen (Auteur), Jastaranpreet Singh (Auteur), Sabah Asad (Auteur), Danila Leontyev (Auteur), Stanley Read (Auteur), Juan Carlos Zúñiga-Pflücker (Auteur), Sadhna Joshi (Auteur)
• Format: Livre
• Publié: Elsevier, 2017-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

HIV entry inhibitors are highly effective in controlling virus replication. We have developed a lentiviral vector that expresses a secreted entry inhibitor, soluble CD4 (sCD4), which binds to the HIV envelope glycoproteins and inactivates the virus. We have shown that sCD4 was secreted from gene-mod...