Control of HIV Infection In Vivo Using Gene Therapy with a Secreted Entry Inhibitor

• Main Authors: Alexander Falkenhagen (Author), Jastaranpreet Singh (Author), Sabah Asad (Author), Danila Leontyev (Author), Stanley Read (Author), Juan Carlos Zúñiga-Pflücker (Author), Sadhna Joshi (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HIV entry inhibitors are highly effective in controlling virus replication. We have developed a lentiviral vector that expresses a secreted entry inhibitor, soluble CD4 (sCD4), which binds to the HIV envelope glycoproteins and inactivates the virus. We have shown that sCD4 was secreted from gene-mod...