Control of HIV Infection In Vivo Using Gene Therapy with a Secreted Entry Inhibitor

• Asıl Yazarlar: Alexander Falkenhagen (Yazar), Jastaranpreet Singh (Yazar), Sabah Asad (Yazar), Danila Leontyev (Yazar), Stanley Read (Yazar), Juan Carlos Zúñiga-Pflücker (Yazar), Sadhna Joshi (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2017-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

HIV entry inhibitors are highly effective in controlling virus replication. We have developed a lentiviral vector that expresses a secreted entry inhibitor, soluble CD4 (sCD4), which binds to the HIV envelope glycoproteins and inactivates the virus. We have shown that sCD4 was secreted from gene-mod...