Cathepsin K activity controls cachexia‐induced muscle atrophy via the modulation of IRS1 ubiquitination

• Main Authors: Xiangkun Meng (Author), Zhe Huang (Author), Aiko Inoue (Author), Hailong Wang (Author), Ying Wan (Author), Xueling Yue (Author), Shengnan Xu (Author), Xueying Jin (Author), Guo‐Ping Shi (Author), Masafumi Kuzuya (Author), Xian Wu Cheng (Author)
• Format: Book
• Published: Wiley, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cachexia is a complicated metabolic disorder that is characterize by progressive atrophy of skeletal muscle. Cathepsin K (CTSK) is a widely expressed cysteine protease that has garnered attention because of its enzymatic and non‐enzymatic functions in signalling in various pathol...